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Lucio's phenomenon : ウィキペディア英語版 | Lucio's phenomenon Lucio's phenomenon is an unusual reaction seen almost exclusively in patients from the Caribbean and Mexico with diffuse, lepromatous leprosy, especially in untreated cases. It is characterised by recurrent crops of large, sharply demarcated, ulcerative lesions, affecting mainly the lower extremities, but may generalise and become fatal as a result of secondary bacterial infection and sepsis.〔Kasper DL, Braunwald E, Fauci AS, et al. Harrison's Principles of Internal Medicine. 16th edition. McGraw-Hill. 2005. Vol I. p.969.〕 Lucio's phenomenon was first described by Rafael Lucio Nájera and Alvarado as a necrotizing skin reaction associated with non-nodular diffuse leprosy in 1852. This reaction was later named by Latapi and Zamora in 1948 as Lucio's phenomenon after identification of histopathological changes involving multiple, acute and necrotizing cutaneous vasculitis peculiar to pure and primitive diffuse leprosy (PPDL).〔Latapi F, Zamora AC. La lepra "manchada" de Lucio (estudio inicial clinico e histopatologico). In: Memoria do V Congreso International de la Lepra - Havana, 1948, pp. 410-413.〕〔Latapi F, Zamora AC. The "spotted" Leprosy of Lucio (La lepra "manchada" de Lucio); an introduction to its clinical and histological study. Int. J. Lepr. 16 (1948) 421-429.〕 ==Pathogenesis== The mechanism of pathogenesis is thought to be mediated by immune-complex deposition.〔
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